Iberiotoxin

• Description :

  Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca2+-activated K+ channel (KCa1.1) at nanomolar concentrations (IC50 ~2 nM) . This toxin does not affect other types of calcium-dependent or voltage-dependent K+ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.

• Specifications :

  Blocker of high conductance Ca2+-activated K+ channel

• Target :

  K channels

• Sequence :

  FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ

• Peptide Number :

  12IBX001

• Disulfide Bonds :

  Cys7-Cys28; Cys13-Cys33; Cys17-Cys35

• N Terminal Sequence :

  PQ

• C Terminal Sequence :

  OH

• CAS Number :

  129203-60-7