Margatoxin

• Description:

  Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM) . Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.

• Specifications:

  Kv1.3 selective blocker

• Target:

  K channels

• Sequence:

  TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH

• Peptide Number:

  08MAG001

• Disulfide Bonds:

  Cys7-Cys29; Cys13-Cys34; Cys17-Cys36

• N Terminal Sequence:

  H

• C Terminal Sequence:

  OH

• CAS Number:

  145808-47-5