MitTx

• Description:

  MitTx is a peptide isolated from the Venom of the Texas coral snake Micrurus tener tener. MitTx is a selective agonist for acid-sensing ion channels 1 (ASIC1s) and produces a similar effect than pH drops. MitTx activates both ASIC1a & ASIC1b with a higher selectivity for ASIC1a (EC50 = 9.4 nM) compared to the ASIC1b (EC50= 23 nM) . MitTx also demonstrates an activity for ASIC3 with a lower potency (EC50=830 nM) .The venom toxin MitTx is an heterodimer composed of an α subunit of ~ 7 kDa and a β subunit of ~ 13.5 kDa. These two subunits when isolated do not present activity against ASIC channels. In vivo, the heterodimer elicits a robust pain-related behavior in mice by activation of ASIC1 channels on capsaicin-sensitive nerve fibers

• Specifications:

  ASIC1a/1b agonist

• Target:

  ASIC channels

• Sequence:

  MitTx-α subunit: QIRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG MitTx-β subunit: NLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLDRCCQAQKQCYDEAVKVHGCKPL VMFYSFECRYLASDLDCSGNNTKCRNFVCNCDRTATLCILTATYNRNNHKIDPSRCQ

• Peptide Number:

  MTX002

• Disulfide Bonds:

  Mit-αsubunit:Cys31-Cys82; Cys41-Cys65; Cys57-Cys78/Mit-βsubunit:Cys41-Cys100; Cys55-Cys148; Cys57-Cys73; Cys72-Cys130; Cys79-Cys123; Cys89-Cys116; Cys109-Cys121

• N Terminal Sequence:

  H

• C Terminal Sequence:

  OH