ρ-Da1a (AdTx1)

CAT: 0466-ADT001-00010Size: 0.01 mgDry Ice: NoHazardous: No

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CAT#:0466-ADT001-00010Size:0.01 mg

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Description

AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep) . AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K (i) = 0.35 nM) and high specificity for the human alpha (1A) -adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.

Specifications

Selective antagonist of the alpha (1A) -adrenoceptor

Target

GPCR

Sequence

LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDSTRGCAATCPIPENYDSIHCCKTDKCNE

Peptide Number

ADT001

Disulfide Bonds

Cys3-Cys24; Cys17-Cys42; Cys46-Cys57; Cys58-Cys63

N Terminal Sequence

C Terminal Sequence

Alternative Products

Catalog	Name
PP51212	ρ-Da1a (AdTx1)
TP2086	AdTx1
MBS1158451-01	Recombinant Dendroaspis angusticeps Toxin AdTx1

ρ-Da1a (AdTx1)

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