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MitTx

CAT: 0466-MTX002-00010Size: 0.01 mgDry Ice: NoHazardous: No
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CAT#:0466-MTX002-00010Size:0.01 mg
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Description
MitTx is a peptide isolated from the Venom of the Texas coral snake Micrurus tener tener. MitTx is a selective agonist for acid-sensing ion channels 1 (ASIC1s) and produces a similar effect than pH drops. MitTx activates both ASIC1a & ASIC1b with a higher selectivity for ASIC1a (EC50 = 9.4 nM) compared to the ASIC1b (EC50= 23 nM) . MitTx also demonstrates an activity for ASIC3 with a lower potency (EC50=830 nM) .The venom toxin MitTx is an heterodimer composed of an α subunit of ~ 7 kDa and a β subunit of ~ 13.5 kDa. These two subunits when isolated do not present activity against ASIC channels. In vivo, the heterodimer elicits a robust pain-related behavior in mice by activation of ASIC1 channels on capsaicin-sensitive nerve fibers
Specifications
ASIC1a/1b agonist
Target
ASIC channels
Sequence
MitTx-α subunit: QIRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG MitTx-β subunit: NLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLDRCCQAQKQCYDEAVKVHGCKPL VMFYSFECRYLASDLDCSGNNTKCRNFVCNCDRTATLCILTATYNRNNHKIDPSRCQ
Peptide Number
MTX002
Disulfide Bonds
Mit-αsubunit:Cys31-Cys82; Cys41-Cys65; Cys57-Cys78/Mit-βsubunit:Cys41-Cys100; Cys55-Cys148; Cys57-Cys73; Cys72-Cys130; Cys79-Cys123; Cys89-Cys116; Cys109-Cys121
N Terminal Sequence
H
C Terminal Sequence
OH

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PP51181MitTx
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GTR18880890-01Reptile Kunitz-type neurotoxin MitTx-alpha protein
CSB-EP516846MUA-01Recombinant Micrurus tener tener Kunitz-type neurotoxin MitTx-alpha
OPCA02980-500UGOPCA02980-500UG - Kunitz-type neurotoxin MitTx-alpha Recombinant Protein
373967-01Kunitz-Type Neurotoxin MitTx-alpha, Recombinant, Micrurus Tener Tener, aa25-84, His-Tag
MBS7179966Rabbit anti-Micrurus tener tener (Texas coral snake) Kunitz-type neurotoxin MitTx-alpha Polyclonal Antibody

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