Iberiotoxin

• Description:

  Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca2+-activated K+ channel (KCa1.1) at nanomolar concentrations (IC50 ~2 nM) . This toxin does not affect other types of calcium-dependent or voltage-dependent K+ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.

• Specifications:

  Blocker of high conductance Ca2+-activated K+ channel

• Target:

  K channels

• Sequence:

  FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ

• Peptide Number:

  12IBX001

• Disulfide Bonds:

  Cys7-Cys28; Cys13-Cys33; Cys17-Cys35

• N Terminal Sequence:

  PQ

• C Terminal Sequence:

  OH

• CAS Number:

  129203-60-7