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Crotamine

CAT: 0466-CRO01-00100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0466-CRO01-00100Size:0.1 mg
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Description
Crotamine is a basic peptide present in the venom of the South American rattlesnake Crotalus durissus terrificus. Multiple biological functions have been attributed to Crotamine. It is a natural cell-penetrating peptide with selective biological action towards actively proliferating cell types. Moreover, it has been reported that crotamine is a blocker of Kv1.3 (IC50 around 300 nM) as well as Kv1.1 and Kv1.2. It has analgesic properties and myonecrotic effects. In addition, crotamine belongs to the beta-defensin peptides and as such demonstrates antibacterial properties by interacting with lipid membranes.
Specifications
Blocker of Kv1.3, Kv1.1 and Kv1.2 channels / Cell Penetrating Peptide
Target
Others
Sequence
YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG
Peptide Number
CRO001
Disulfide Bonds
Cys4-Cys36; Cys11-Cys30; Cys18-Cys37
N Terminal Sequence
H
C Terminal Sequence
OH