Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag

• Background:

  Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD) . Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

• Description:

  Human Alpha-Synuclein Pre-formed Fibrils, His Tag (ALN-H51H4) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1) .

• Specifications:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa.

• Accession Number:

  P37840-1

• Expression Region:

  Met 1 - Ala 140

• Host:

  E. coli

• Target:

  Alpha-Synuclein

• Conjugation:

  Unconjugated

• Tag:

  C-10xHis

• Stability:

  ● The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C; ● The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions; ● The sonicated fibril should be stored at -70°C for not more than 8 weeks.

• Endotoxin:

  1.0 EU per μg

• Purity:

  90%

• Format:

  Liquid

• Buffer:

  PBS, pH7.4

• Molecular Weight:

  16.3 kDa

• Shipping Conditions:

  Dry ice

• Storage Conditions:

  -70°C

• Package Size:

  500ug*1

• Species:

  Human