Solifenacin

CAT: 0804-HY-A0034-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-A0034-02Size:10 mM - 1 mL

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Description

Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

CAS Number

242478-37-1

Product Name Alternative

YM905 (free base)

UNSPSC

12352005

Hazard Statement

H361

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Solifenacin.html

Purity

99.77

Solubility

DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(O[C@@]1([H])C[N@]2CC[C@@H]1CC2)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5

Molecular Formula

C23H26N2O2

Molecular Weight

362.46

Precautions

H361

References & Citations

[1]Ikeda K, et al. M (3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366 (2) :97-103.|[2]Suzuki M, et al. Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarctedrats. Eur J Pharmacol. 2005 Apr 4;512 (1) :61-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

MAChR1; mAChR2; mAChR3

Citation 01

Int J Nanomedicine. 2024 Aug 15:19:8353-8371.|J Chem Neuroanat. 2024 Mar:136:102375.|Neurourol Urodyn. 2017 Apr;36 (4) :1026-1033.

Chemical Information

Solifenacin

Solifenacin is a member of isoquinolines.

CAS Number	242478-37-1
PubChem CID	154059
IUPAC Name	[(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
Molecular Formula	C23H26N2O2
Molecular Weight	362.5
XLogP	4
Topological Polar Surface Area	32.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	524

SMILES

C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5

InChI

InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1

InChIKey

FBOUYBDGKBSUES-VXKWHMMOSA-N

Chemical Structure

2D Structure

CAS: 242478-37-1

CID: 154059

Formula: C23H26N2O2

MW: 362.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	362.5
XLogP3	4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	362.199428076
Monoisotopic Mass	362.199428076
Topological Polar Surface Area	32.8 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	524
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
OR1029754-01	Solifenacin
B3415-50	Solifenacin hydrochloride
CS-O-10053	Solifenacin-d5
RM-S120601-01	Solifenacin Impurity A
MBS132077-01	Solifenacin succinate
A16947-500	Solifenacin 500mg
A16947-100	Solifenacin 100mg
A16947-50	Solifenacin 50mg

Solifenacin

Chemical Information

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