4μ8C

CAT: 0804-HY-19707-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-19707-01Size:5 mg

Selected

PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Description

4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.

CAS Number

[14003-96-4]

Product Name Alternative

IRE1 Inhibitor III

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4_mu_8C.html

Purity

99.95

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=CC1=C(O)C=CC2=C1OC(C=C2C)=O

Molecular Formula

C11H8O4

Molecular Weight

204.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Cross BC, et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A. 2012 Apr 10;109 (15) :E869-78.|[2]Zhang L, et al. IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis. BMC Cell Biol. 2014 Jul 10;15:29.|[3]Kemp K, et al. The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem. 2013 Nov 15;288 (46) :33272-82.|[4]Tufanli O, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017 Feb 21;114 (8) :E1395-E1404.|[5]Nam ST, et al. Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Sykactivation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C. Toxicol Appl Pharmacol. 2017 Oct 1;332:25-31.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-P7348	FGF-8c, Mouse
HY-P7348A-01	FGF-8c, Mouse (His)
HY-W099255-01	Ethyl 4,4,4,4',4',4'-hexafluoro-DL-valinate
HY-W720006	4,4'-Diapo-ω, ω-carotene-4,4'-dial
HY-77910-01	4- (4-Bromophenyl) -4-hydroxypiperidine
HY-W011927-01	4,4'-Sulfonyldiphenol
HY-103610-01	4,4'-Dimethoxybenzil
HY-W269747	4,4'-Dimethoxyoctafluorobiphenyl
HY-136064-01	4,4'-Dimethoxychalcone
HY-W011918	4,4'-Dichlorobenzophenone

Alternative Products

Catalog	Name
bs-82328C-01	4μ8C
OR1023959-01	4µ8C
530969	4Î¼8C
T6363-01	4?8C
A13803-100	4μ8C 100mg
A13803-500	4μ8C 500mg
A13803-5	4μ8C 5mg
TBI1579-25MG	4µ8C, IRE1 ribonuclease inhibitor
MBS5768585	BCL6-IN-8c
PR15017	FGF-8c

4μ8C

Related Products

Alternative Products

Popular Products