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FT709

CAT: 0804-HY-145967-03Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-145967-03Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms[1].
CAS Number
2413991-74-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Deubiquitinase; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ft709.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CN=C2C(OCCO2)=C1)(N3CC(CN(C([C@@H](O)C4=CC=CC5=C4N=C(C)O5)=O)C6)=C6C3)=O
Molecular Formula
C23H22N4O7S
Molecular Weight
498.51
Precautions
H302, H315, H319
References & Citations
[1]Clancy A, et, al. The deubiquitylase USP9X controls ribosomal stalling. J Cell Biol. 2021 Mar 1;220 (3) :e202004211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(S)-1-(5-((2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-hydroxy-2-(2-methylbenzo[d]oxazol-4-yl)ethan-1-one
CAS Number2413991-74-7
PubChem CID146448154
IUPAC Name(2S)-1-[5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylsulfonyl)-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-2-hydroxy-2-(2-methyl-1,3-benzoxazol-4-yl)ethanone
Molecular FormulaC23H22N4O7S
Molecular Weight498.5
XLogP-0.5
Topological Polar Surface Area144
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity967
SMILES
CC1=NC2=C(C=CC=C2O1)[C@@H](C(=O)N3CC4=C(C3)CN(C4)S(=O)(=O)C5=CC6=C(N=C5)OCCO6)O
InChI
InChI=1S/C23H22N4O7S/c1-13-25-20-17(3-2-4-18(20)34-13)21(28)23(29)26-9-14-11-27(12-15(14)10-26)35(30,31)16-7-19-22(24-8-16)33-6-5-32-19/h2-4,7-8,21,28H,5-6,9-12H2,1H3/t21-/m0/s1
InChIKey
SCFWBZTVFCUBIZ-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of (S)-1-(5-((2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-hydroxy-2-(2-methylbenzo[d]oxazol-4-yl)ethan-1-one
CAS: 2413991-74-7
CID: 146448154
Formula: C23H22N4O7S
MW: 498.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight498.5
XLogP3-0.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass498.12092023
Monoisotopic Mass498.12092023
Topological Polar Surface Area144 Ų
Heavy Atom Count35
Formal Charge0
Complexity967
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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