CaMKIIα-IN-1

CaMKIIα-IN-1

• CAS Number: 3031484-08-6
• UNSPSC Description: CaMKIIα-IN-1 (Compound 4d) is an orally active Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a KD of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability[1].
• Target Antigen: CaMK
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/camkiiα-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CC1=CC(O)=CC=C1OC2=CC=CC=C2Cl)O
• Molecular Weight: 278.69
• References & Citations: [1]Tian Y, et al. Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain. J Med Chem. 2022 May 12;65(9):6656-6676.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported