LEI110

CAT: 0804-HY-125254-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-125254-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells[1].

CAS Number

2313525-90-3

UNSPSC

12352005

Target

HRASLS; Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lei110.html

Purity

99.72

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCCC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(CCCC3=CC=CC=C3)=O

Molecular Formula

C25H23F3N2O3

Molecular Weight

456.46

References & Citations

[1]Zhou J, et al. Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI. ACS Chem Biol. 2019 Feb 15;14 (2) :164-169.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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