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LEI110

CAT: 0013-GTR19166782-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166782-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LEI110 is a potent and selective pan-inhibitor of the HRASLS thiol hydrolase family, including PLA2G16 (Ki=20 nM), HRASLS2, RARRES3, and iNAT. This small molecule is a valuable research tool for studying lipid metabolism and signaling in both cellular and animal models of metabolic disorders and cancer.
CAS Number
2313525-90-3
Product Name Alternative
Inhibit, lipolysis, Inhibitor, HepG2 cells, LEI 110, LEI110, LEI-110, thiol hydrolases, PLA2G16, Phospholipase
Field of Research
Metabolism Research
Purity
97.56% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:2.5 mg/mL (5.48 mM) ; DMSO:50 mg/mL (109.54 mM)
Smiles
FC (F) (F) c1ccc (Oc2ccc (CCNC (=O) C (=O) CCCc3ccccc3) cc2) nc1
Molecular Formula
C25H23F3N2O3
Molecular Weight
456.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide
CAS Number2313525-90-3
PubChem CID156013201
IUPAC Name2-oxo-5-phenyl-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]pentanamide
Molecular FormulaC25H23F3N2O3
Molecular Weight456.5
XLogP5.3
Topological Polar Surface Area68.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count33
Formal Charge0
Complexity615
SMILES
C1=CC=C(C=C1)CCCC(=O)C(=O)NCCC2=CC=C(C=C2)OC3=NC=C(C=C3)C(F)(F)F
InChI
InChI=1S/C25H23F3N2O3/c26-25(27,28)20-11-14-23(30-17-20)33-21-12-9-19(10-13-21)15-16-29-24(32)22(31)8-4-7-18-5-2-1-3-6-18/h1-3,5-6,9-14,17H,4,7-8,15-16H2,(H,29,32)
InChIKey
DZHZISUSQMPBJQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide
CAS: 2313525-90-3
CID: 156013201
Formula: C25H23F3N2O3
MW: 456.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.5
XLogP35.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass456.16607709
Monoisotopic Mass456.16607709
Topological Polar Surface Area68.3 Ų
Heavy Atom Count33
Formal Charge0
Complexity615
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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