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Aristolochic acid A

CAT: 0804-HY-N0510-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0510-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].
CAS Number
313-67-7
Product Name Alternative
Aristolochic acid I; TR 1736
UNSPSC
12352005
Hazard Statement
H301, H340, H350
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aristolochic-acid-a.html
Purity
99.91
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
OC(C1=CC2=C(OCO2)C3=C4C(C(OC)=CC=C4)=CC([N+]([O-])=O)=C31)=O
Molecular Formula
C17H11NO7
Molecular Weight
341.27
Precautions
H301, H340, H350
References & Citations
[1]Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137.|[2]Chenchen Feng, et al. Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A. Environ Toxicol Pharmacol. 2013 Nov;36 (3) :850-7.|[3]Youjia Zeng, et al. Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model. Apoptosis. 2014 Aug;19 (8) :1215-24.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched

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T2801-01Aristolochic acid A
MBS3604010-01Aristolochic Acid
259694-01Aristolochic acid C
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