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RASF5 rabbit pAb

CAT: 0855-ES13460-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13460-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q8WWW0
Swiss Prot
Q8WWW0
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human RASF5 AA range: 234-284
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Gene ID (Human)
83593

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