Allylthiourea

Allylthiourea

• CAS Number: 109-57-9
• UNSPSC Description: Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies[1][2][3][4].
• Target Antigen: Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/allylthiourea.html
• Purity: 98.0
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: S=C(N)NCC=C
• Molecular Weight: 116.18
• References & Citations: [1]Ginestet, P., et al., Estimation of nitrifying bacterial activities by measuring oxygen uptake in the presence of the metabolic inhibitors allylthiourea and azide. Appl Environ Microbiol, 1998. 64(6): p. 2266-8.|[2]Yu, Y., J.A. Ramsay, and B.A. Ramsay, Use of allylthiourea to produce soluble methane monooxygenase in the presence of copper. Appl Microbiol Biotechnol, 2009. 82(2): p. 333-9.|[3]Tatari K, et al. Challenges in using allylthiourea and chlorate as specific nitrification inhibitors[J]. Chemosphere, 2017, 182: 301-305.|[4]Widiandani T, et al. New N-allylthiourea derivatives: synthesis, molecular docking and in vitro cytotoxicity studies[J]. Tropical Journal of Pharmaceutical Research, 2018, 17(8): 1607-1613.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported