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Allylthiourea

CAT: 0804-HY-B0543-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0543-01Size:25 g
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Description
Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies[1][2][3][4].
CAS Number
109-57-9
Product Name Alternative
Thiosinamine; N-Allylthiourea
UNSPSC
12352211
Hazard Statement
H301
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/allylthiourea.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
S=C(N)NCC=C
Molecular Formula
C4H8N2S
Molecular Weight
116.18
Precautions
H301
References & Citations
[1]Ginestet, P., et al., Estimation of nitrifying bacterial activities by measuring oxygen uptake in the presence of the metabolic inhibitors allylthiourea and azide. Appl Environ Microbiol, 1998. 64 (6) : p. 2266-8.|[2]Yu, Y., J.A. Ramsay, and B.A. Ramsay, Use of allylthiourea to produce soluble methane monooxygenase in the presence of copper. Appl Microbiol Biotechnol, 2009. 82 (2) : p. 333-9.|[3]Tatari K, et al. Challenges in using allylthiourea and chlorate as specific nitrification inhibitors[J]. Chemosphere, 2017, 182: 301-305.|[4]Widiandani T, et al. New N-allylthiourea derivatives: synthesis, molecular docking and in vitro cytotoxicity studies[J]. Tropical Journal of Pharmaceutical Research, 2018, 17 (8) : 1607-1613.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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