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Oncrasin-1

CAT: 0804-HY-16662-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16662-01Size:10 mg
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Description
Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer[1][2].
CAS Number
75629-57-1
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Apoptosis; DNA/RNA Synthesis; Ras
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Oncrasin-1.html
Concentration
10mM
Purity
98.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
Molecular Formula
C16H12ClNO
Molecular Weight
269.73
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Guo W, et al. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. Cancer Res. 2008 Sep 15;68 (18) :7403-8.|[2]Guo W, et al. Interruption of RNA processing machinery by a small compound, 1-[ (4-chlorophenyl) methyl]-1H-indole-3-carboxaldehyde (oncrasin-1) . Mol Cancer Ther. 2009 Feb;8 (2) :441-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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