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Brazilin

CAT: 0804-HY-N0072-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0072-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities[1][2][3].
CAS Number
474-07-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/brazilin.html
Concentration
10mM
Purity
99.37
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=CC=C([C@]2([H])[C@](CC3=C2C=C(O)C(O)=C3)(O)CO4)C4=C1
Molecular Formula
C16H14O5
Molecular Weight
286.28
Precautions
H315, H319, H335
References & Citations
[1]Dapson RW, et al. Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. Biotech Histochem. 2015;90 (6) :401-23.|[2]Jia Y, et al. [Effect of brazilin on apoptosis and autophagy of tongue cancer Tca8113 cells and its molecular mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 Mar 30;39 (3) :351-356.|[3]Weinmann D, et al, Brazilin blocks catabolic processes in human osteoarthritic chondrocytes via inhibition of NFKB1/p50. J Orthop Res. 2018 Sep;36 (9) :2431-2438.|[4]Xi Wang, et al. Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice. Biol Pharm Bull. 2019, 42, 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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