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KY19382

CAT: 0804-HY-131447-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131447-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases[1][2].
CAS Number
2226664-93-1
Product Name Alternative
A3051
UNSPSC
12352005
Hazard Statement
H315, H319
Target
GSK-3; Wnt; β-catenin
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ky19382.html
Purity
98.0
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1NC2=C(C=C(Cl)C(Cl)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OC
Molecular Formula
C17H11Cl2N3O2
Molecular Weight
360.19
Precautions
H315, H319
References & Citations
[1]Choi S, et, al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci Alliance. 2019 Apr 10; 2 (2) : e201800254.|[2]Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β

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