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KY19382

CAT: 0013-GTR19155906-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155906-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β (IC50s of 19 and 10 nM, respectively) . It activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.
CAS Number
2226664-93-1
Product Name Alternative
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3- (methoxyimino) -2H-indol-2-ylidene]-1,3-dihydro-Ky19382 | A3051
Purity
>98% (HPLC)
Solubility
DMSO:5 mg/mL (13.88 mM; Need ultrasonic)
Smiles
CO/N=C\1/C2=CC=CC=C2N=C1C3=C (NC4=CC (=C (C=C43) Cl) Cl) O
Molecular Formula
C17H11Cl2N3O2
Molecular Weight
360.2
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

CID 148959784
CAS Number2226664-93-1
PubChem CID148959784
IUPAC Name5,6-dichloro-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol
Molecular FormulaC17H11Cl2N3O2
Molecular Weight360.2
XLogP4.6
Topological Polar Surface Area70
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity556
SMILES
CO/N=C\1/C2=CC=CC=C2N=C1C3=C(NC4=CC(=C(C=C43)Cl)Cl)O
InChI
InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,21,23H,1H3/b22-15-
InChIKey
TVZDUDDLASVAOM-JCMHNJIXSA-N
Chemical Structure
2D Structure
2D structure of CID 148959784
CAS: 2226664-93-1
CID: 148959784
Formula: C17H11Cl2N3O2
MW: 360.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight360.2
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass359.0228320
Monoisotopic Mass359.0228320
Topological Polar Surface Area70 Ų
Heavy Atom Count24
Formal Charge0
Complexity556
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA8690-25KY19382
C11601-25mgKY19382 (A3051)

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