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CB096

CAT: 0804-HY-W141374-03Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W141374-03Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CB096 binds the 5′CGG/3′GGC internal loop structure of r (G4C2) exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells[1].
CAS Number
108883-90-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cb096.html
Purity
98.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
Molecular Formula
C14H11N3O4
Molecular Weight
285.25
Precautions
H302, H315, H319
References & Citations
[1]Ursu A, et al., Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020 Dec 18;15 (12) :3112-3123.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-Methoxy-4-(6-nitro-1H-benzo[D]imidazol-2-YL)phenol
CAS Number108883-90-5
PubChem CID4460926
IUPAC Name2-methoxy-4-(6-nitro-1H-benzimidazol-2-yl)phenol
Molecular FormulaC14H11N3O4
Molecular Weight285.25
XLogP2.6
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity389
SMILES
COC1=C(C=CC(=C1)C2=NC3=C(N2)C=C(C=C3)[N+](=O)[O-])O
InChI
InChI=1S/C14H11N3O4/c1-21-13-6-8(2-5-12(13)18)14-15-10-4-3-9(17(19)20)7-11(10)16-14/h2-7,18H,1H3,(H,15,16)
InChIKey
LSNPOGOZVAHETR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Methoxy-4-(6-nitro-1H-benzo[D]imidazol-2-YL)phenol
CAS: 108883-90-5
CID: 4460926
Formula: C14H11N3O4
MW: 285.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight285.25
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass285.07495584
Monoisotopic Mass285.07495584
Topological Polar Surface Area104 Ų
Heavy Atom Count21
Formal Charge0
Complexity389
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
OR1006032CB096

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