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CB096

CAT: 0804-HY-W141374-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W141374-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CB096 binds the 5′CGG/3′GGC internal loop structure of r (G4C2) exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells[1].
CAS Number
108883-90-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cb096.html
Purity
98.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
Molecular Formula
C14H11N3O4
Molecular Weight
285.25
Precautions
H302, H315, H319
References & Citations
[1]Ursu A, et al., Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020 Dec 18;15 (12) :3112-3123.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
OR1006032CB096

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