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Remacemide

CAT: 0804-HY-160604-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-160604-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Remacemide (FPL 12924) is an orally active, non-competitive, low-affinity NMDA receptor antagonist. Remacemide shows neuroprotection activity in animal models of hypoxia and ischemic stroke. Remacemide is also an anticonvulsant, and can be used in Parkinson's disease and Huntington's disease research[1][2][3][4].
CAS Number
128298-28-2
Product Name Alternative
FPL 12924; PR 934-423; FPL 13592
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/remacemide.html
Purity
99.88
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
O=C(CN)NC(C)(CC1=CC=CC=C1)C2=CC=CC=C2
Molecular Formula
C17H20N2O
Molecular Weight
268.35
References & Citations
[1]Schachter SC, et al. Remacemide: current status and clinical applications. Expert Opin Investig Drugs. 2000 Apr;9 (4) :871-83.|[2]Dyker AG, et al. Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke. Stroke. 1999 Sep;30 (9) :1796-801.|[3]Greenamyre JT, et al. Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease. Ann Neurol. 1994 Jun;35 (6) :655-61. |[4]Kieburtz K, et al. A controlled trial of remacemide hydrochloride in Huntington's disease. Mov Disord. 1996 May;11 (3) :273-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
NMDA Receptor

Chemical Information

Remacemide

2-amino-N-(1,2-diphenylpropan-2-yl)acetamide is a stilbenoid.

CAS Number128298-28-2
PubChem CID60511
IUPAC Name2-amino-N-(1,2-diphenylpropan-2-yl)acetamide
Molecular FormulaC17H20N2O
Molecular Weight268.35
XLogP2.3
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Heavy Atom Count20
Formal Charge0
Complexity306
SMILES
CC(CC1=CC=CC=C1)(C2=CC=CC=C2)NC(=O)CN
InChI
InChI=1S/C17H20N2O/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14/h2-11H,12-13,18H2,1H3,(H,19,20)
InChIKey
YSGASDXSLKIKOD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Remacemide
CAS: 128298-28-2
CID: 60511
Formula: C17H20N2O
MW: 268.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight268.35
XLogP32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass268.157563266
Monoisotopic Mass268.157563266
Topological Polar Surface Area55.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity306
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T71969-01Remacemide
B6805-50Remacemide hydrochloride
326897Remacemide HCl

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