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Apatorsen (sodium)

CAT: 0804-HY-145722-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145722-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
CAS Number
915443-09-3
Product Name Alternative
OGX-427 (sodium)
UNSPSC
12352208
Target
HSP
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apatorsen-sodium.html
Purity
98.54
Solubility
10 mM in H2O
Smiles
[Apatorsen(sodium)]
Molecular Formula
C224H285N79Na19O116P19S19
Molecular Weight
7157 (free acid)
References & Citations
[1]Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36 (2) :278-287. |[2]Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24 (12) :e1409-e1416.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2

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