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TCB2

CAT: 0804-HY-103102-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-103102-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCB2 is an agonist of serotonin 5-HT2A receptor.
CAS Number
912342-28-0
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/TCB2.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 25 mg/mL (ultrasonic)
Smiles
NCC1C2=C(OC)C=C(Br)C(OC)=C2C1.[H]Br
Molecular Formula
C11H15Br2NO2
Molecular Weight
353.05
References & Citations
[1]Fox MA, et al. The serotonin 5-HT (2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology (Berl) . 2010 Sep;212 (1) :13-23.|[2]Dasiel O. Borroto-Escuela, et al. Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS Omega. 2017 Aug 31; 2 (8) : 4779–4789.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin

Chemical Information

CID 16086372
CAS Number912342-28-0
PubChem CID16086372
IUPAC Name[(7S)-3-bromo-2,5-dimethoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl]methanamine;hydrobromide
Molecular FormulaC11H15Br2NO2
Molecular Weight353.05
Topological Polar Surface Area44.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count16
Formal Charge0
Complexity227
SMILES
COC1=CC(=C(C2=C1[C@H](C2)CN)OC)Br.Br
InChI
InChI=1S/C11H14BrNO2.BrH/c1-14-9-4-8(12)11(15-2)7-3-6(5-13)10(7)9;/h4,6H,3,5,13H2,1-2H3;1H/t6-;/m1./s1
InChIKey
TYMMXVZAUGQKRF-FYZOBXCZSA-N
Chemical Structure
2D Structure
2D structure of CID 16086372
CAS: 912342-28-0
CID: 16086372
Formula: C11H15Br2NO2
MW: 353.05
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight353.05
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass352.94490
Monoisotopic Mass350.94695
Topological Polar Surface Area44.5 Ų
Heavy Atom Count16
Formal Charge0
Complexity227
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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