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Sulopenem

CAT: 0804-HY-105284-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105284-01Size:5 mg
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Description
Sulopenem (CP-70429) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia[1][2][3].
CAS Number
120788-07-0
Product Name Alternative
CP-70429
UNSPSC
12352005
Target
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sulopenem.html
Purity
99.16
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(S[C@@H](CC3)C[S@@]3=O)S[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
Molecular Formula
C12H15NO5S3
Molecular Weight
349.45
References & Citations
[1]James A Karlowsky, et al. In Vitro Activity of Sulopenem, an Oral Penem, Against Urinary Isolates of Escherichia coli. Antimicrob Agents Chemother. 2018 Dec 21;63 (1) :e01832-18.|[2]M Minamimura, et al. In Vitro Antibacterial Activity and Beta-Lactamase Stability of CP-70,429 a New Penem Antibiotic. Antimicrob Agents Chemother. 1993 Jul;37 (7) :1547-51.|[3]M Nagashima, et al. In Vitro and in Vivo Activities of Sulopenem Compared With Those of Imipenem and Cephalosporins. Jpn J Antibiot. 1996 Apr;49 (4) :303-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
β-lactam

Chemical Information

Sulopenem

Sulopenem is a penem antibacterial. It is marketed as the prodrug [sulopenem etzadroxil] in combination with [probenecid].

CAS Number120788-07-0
PubChem CID9950244
IUPAC Name(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(1R,3S)-1-oxothiolan-3-yl]sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Molecular FormulaC12H15NO5S3
Molecular Weight349.5
XLogP0
Topological Polar Surface Area165
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity563
SMILES
C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(S2)S[C@H]3CC[S@@](=O)C3)C(=O)O)O
InChI
InChI=1S/C12H15NO5S3/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6/h5-7,10,14H,2-4H2,1H3,(H,16,17)/t5-,6+,7+,10-,21-/m1/s1
InChIKey
FLSUCZWOEMTFAQ-PRBGKLEPSA-N
Chemical Structure
2D Structure
2D structure of Sulopenem
CAS: 120788-07-0
CID: 9950244
Formula: C12H15NO5S3
MW: 349.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.5
XLogP30
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass349.01123610
Monoisotopic Mass349.01123610
Topological Polar Surface Area165 Ų
Heavy Atom Count21
Formal Charge0
Complexity563
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA1081-1Sulopenem
A22051-1Sulopenem 1mg
T87480-01Sulopenem sodium
A22051-50Sulopenem 50mg
A22051-25Sulopenem 25mg
A22051-500Sulopenem 500mg
A22051-100Sulopenem 100mg
A22051-10Sulopenem 10mg
A22051-5Sulopenem 5mg
A22051-10mM-DSulopenem 10mM * 1mL in DMSO

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