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L-Sepiapterin

CAT: 0804-HY-112234-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112234-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4) . L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia[1][2].
CAS Number
17094-01-8
Product Name Alternative
Sepiapterin
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-sepiapterin.html
Purity
99.50
Solubility
DMSO : 10 mg/mL (ultrasonic;warming)
Smiles
O=C1NC(N)=NC2=C1N=C(C([C@@H](O)C)=O)CN2
Molecular Formula
C9H11N5O3
Molecular Weight
237.22
References & Citations
[1]Pannirselvam M, et al. Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. Br J Pharmacol. 2003;140 (4) :701‐706.|[2]Cho YR, et al. Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep. 2011;26 (4) :861‐867.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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Alternative Products

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RM-S010100-01Sepiapterin (L-Sepiapterin)
sc-506156BL-Sepiapterin
453424-01L-Sepiapterin discontinued
CS-T-103785L-Sepiapterin-13CD3
AR-P03220-01Sepiapterin
GTR19011999-01Sepiapterin reductase
CS-O-63518Sepiapterin-d4
397558SPR (Sepiapterin Reductase)
RM-S010104-01Sepiapterin Impurity 4

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