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​JOE

CAT: 0804-HY-D1090-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1090-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JOE is a fluorescent dye and can be used as a fluorescent label in DNA sequencing, PCR, and LCR amplifications. JOE possesses an absorbance of 525 nm and an emission of 550 nm[1].
CAS Number
82855-40-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA Stain
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/joe.html
Purity
99.59
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2(C3=C(OC4=C2C=C(OC)C(O)=C4Cl)C(Cl)=C(O)C(OC)=C3)O5)=C(C=C1)C5=O)O
Molecular Formula
C23H14Cl2O9
Molecular Weight
505.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Tsybulsky DA, et al. 4',5'-Dichloro-2',7'-dimethoxy-5 (6) -carboxyfluorescein (JOE) : synthesis and spectral properties of oligonucleotide conjugates. J Org Chem. 2012 Jan 20;77 (2) :977-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-Carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein

6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein is a fluorescein compound having chloro substituents in the 4'- and 5'-positions, methoxy substituents in the 2'- and 7'-positions and a carboxy substituent at the 6-position. It has a role as a fluorochrome. It is functionally related to a fluorescein (lactone form).

CAS Number82855-40-1
PubChem CID10229054
IUPAC Name4',5'-dichloro-3',6'-dihydroxy-2',7'-dimethoxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylic acid
Molecular FormulaC23H14Cl2O9
Molecular Weight505.3
XLogP4.1
Topological Polar Surface Area132
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Heavy Atom Count34
Formal Charge0
Complexity790
SMILES
COC1=C(C(=C2C(=C1)C3(C4=CC(=C(C(=C4O2)Cl)O)OC)C5=C(C=CC(=C5)C(=O)O)C(=O)O3)Cl)O
InChI
InChI=1S/C23H14Cl2O9/c1-31-13-6-11-19(15(24)17(13)26)33-20-12(7-14(32-2)18(27)16(20)25)23(11)10-5-8(21(28)29)3-4-9(10)22(30)34-23/h3-7,26-27H,1-2H3,(H,28,29)
InChIKey
IDLISIVVYLGCKO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-Carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein
CAS: 82855-40-1
CID: 10229054
Formula: C23H14Cl2O9
MW: 505.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight505.3
XLogP34.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Exact Mass504.0014874
Monoisotopic Mass504.0014874
Topological Polar Surface Area132 Ų
Heavy Atom Count34
Formal Charge0
Complexity790
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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