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Anti-ICK Antibody

CAT: 1303-75-437Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1303-75-437Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Serine/threonine-protein kinase ICK is encoded by the gene Ick. Ick is a member of the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. Ick has an essential role in ciliogenesis. Ick is envolved in the control of ciliary length by regulating the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. Ick is highly expressed in the colon and lungs, with lower levels of expression in the heart, esophagus, stomach, small intestine, and ovaries. Diseases associated with Ick include endocrine-cerebroosteodysplasia, juvenile myoclonic epilepsy 10, and juvenile myoclonic epilepsy 1.
Description
Our Anti-ICK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N451/73. It detects mouse and rat ICK, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Short Description
Our Anti-ICK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N451/73. It detects mouse and rat ICK, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.
Synonyms
Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK)
Gene Name
Ick
UniProt
Q9JKV2
Host
Mouse
Reactivity
Mouse and Rat
Immunogen
Fusion protein amino acids 290-629 (C-terminus) of mouse ICK (accession number Q9JKV2) produced recombinantly in E. Coli
Target
ICK
Clonality
Monoclonal
Isotype
IgG1
Clone
N451/73
Type
Primary Antibody
Applications
WB, IHC, ICC, ELISA
Field of Research
Rare Diseases
Concentration
1 mg/mL
Format
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Molecular Weight
70 kDa
Shipping Conditions
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Specificity
No cross-reactivity reported
Quality Control
Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Mouse
Conjugate
Unconjugated
IHC Quality Control
1
RRID
AB_2576198

UniProtKB · Q9JKV2

Serine/threonine-protein kinase ICK

CILK1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9JKV2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cilk1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
Q8K138
Protein keywords

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell projectionCytoplasmCytoskeletonNucleus

Biological process

Cilium biogenesis/degradation

Molecular function

Developmental proteinKinaseSerine/threonine-protein kinaseTransferase

Technical term

Direct protein sequencingReference proteome

PTM

Phosphoprotein

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