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Anti-CASPR2 Antibody

CAT: 1303-75-075Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1303-75-075Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell–cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy.
Description
Our Anti-CASPR2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K67/25. It is KO validated, detects human, mouse, and rat CASPR2, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Short Description
Our Anti-CASPR2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K67/25. It is KO validated, detects human, mouse, and rat CASPR2, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.
Synonyms
Contactin associated protein-like 2 (Contactin associated protein-like 2, isoform CRA_b)
Gene Name
CNTNAP2 hCG_15499 tcag7.496
UniProt
A0A090N7T7
Host
Mouse
Reactivity
Human, Mouse, and Rat
Immunogen
Fusion protein 96-1265 (extracellular domain) of human Caspr2 (accession number A0A090N7T7) produced recombinantly in E. Coli
Target
CASPR2
Clonality
Monoclonal
Isotype
IgG2a
Clone
K67/25
Type
Primary Antibody
Applications
WB, IHC, ICC, IP, ELISA
Field of Research
Cell Adhesion Molecules
Concentration
1 mg/mL
Format
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.7
Molecular Weight
180 kDa
Shipping Conditions
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
IHC Dilution
1:100
WB Dilution
1:500
Specificity
No cross-reactivity against Caspr/paranodin
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Human
WB Brain Quality Control
1
Conjugate
Unconjugated
RRID
AB_2245198

UniProtKB · A0A090N7T7

Protein information

A0A090N7T7_HUMAN · —

View on UniProt ↗
Primary accession
A0A090N7T7
Review status
Inactive
Gene
—
Protein existence
—
Organism
—
Taxonomy ID
—
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—

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