TAE-1

• Description :

  TAE-1 is a potent inhibitor of AChE and BuChE. TAE-1 also inhibits Aβ fibril formation and aggregation. TAE-1 can be used for the researches of Alzheimer's disease[1].

• CAS Number :

  [1414469-59-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  Amyloid-β; Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tae-1.html

• Purity :

  96.17

• Solubility :

  DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(OCC[N+](C)(C)C)C1=CC=C(OC2=NC(OC3=CC=C(C(OCC[N+](C)(C)C)=O)C=C3)=NC(OC4=CC=C(C(OCC[N+](C)(C)C)=O)C=C4)=N2)C=C1.[I-].[I-].[I-]

• Molecular Formula :

  C39H51I3N6O9

• Molecular Weight :

  1128.57

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Veloso AJ, et al. Biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of Alzheimer's disease. ACS Chem Neurosci. 2013 Jun 19;4 (6) :924-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE