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Bergaptol (Standard)

CAT: 0804-HY-76316R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-76316R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bergaptol (Standard) is the analytical standard of Bergaptol. This product is intended for research and analytical applications. Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties[1].
CAS Number
486-60-2
Product Name Alternative
5-Hydroxypsoralen (Standard) ; 4-Hydroxybergapten (Standard)
UNSPSC
12352005
Target
Cytochrome P450; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bergaptol-standard.html
Smiles
O=C1C=CC(C(O1)=C2)=C(O)C3=C2OC=C3
Molecular Formula
C11H6O4
Molecular Weight
202.16
References & Citations
[2]Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.|[3]Shen CY, et al. Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition. Food Funct. 2020 Jun 24;11 (6) :4915-4926.|[4]Wu J, et al. Bergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway. J Inflamm Res. 2022 Nov 9;15:6199-6211. |[1]Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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