Products for Research Use Only
RegisterLogin

Bergaptol

CAT: 0804-HY-76316-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-76316-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties[1].
CAS Number
486-60-2
Product Name Alternative
5-Hydroxypsoralen; 4-Hydroxybergapten
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Bergaptol.html
Concentration
10mM
Purity
99.30
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C=CC(C(O1)=C2)=C(O)C3=C2OC=C3
Molecular Formula
C11H6O4
Molecular Weight
202.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691|[2]Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.|[3]Shen CY, et al. Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition. Food Funct. 2020 Jun 24;11 (6) :4915-4926.|[4]Wu J, et al. Bergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway. J Inflamm Res. 2022 Nov 9;15:6199-6211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP3

Related Products

CatalogName
HY-N0370-01Bergapten
HY-N0370S-01Bergapten-d3
HY-N0370R-01Bergapten (Standard)

Alternative Products

CatalogName
BA7244-50Bergaptol
A12303-10Bergaptol 10mg
A12303-500Bergaptol 500mg
A12303-25Bergaptol 25mg
A12303-100Bergaptol 100mg

Popular Products