Ensartinib (dihydrochloride)

• UNSPSC Description:

  Ensartinib dihydrochloride (X-396 dihydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.

• Target Antigen:

  Anaplastic lymphoma kinase (ALK); c-Met/HGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ensartinib-dihydrochloride.html

• Purity:

  99.53

• Solubility:

  DMSO : 35.71 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)C=C3.Cl.Cl

• Molecular Weight:

  634.36

• References & Citations:

  [1]Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71(14):4920-31.Drug Des Dev Ther. 2020 Nov 30;14:5259-5273.|Cancer Discov. 2024 Sep 13:OF1-OF20.|Cancers. 2020 Mar 28;12(4):813.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  2137030-98-7