Aloenin

• UNSPSC Description:

  Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release[1][2][3][4].

• Target Antigen:

  Beta-secretase

• Type:

  Natural Products

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aloenin.html

• Purity:

  99.91

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC2=C(C(O3)=CC(OC)=CC3=O)C(C)=CC(O)=C2

• Molecular Weight:

  410.37

• References & Citations:

  [1]Sun YN, et al. Antioxidant and anti-osteoporotic effects of anthraquinones and related constituents from the aqueous dissolved Aloe exudates. Nat Prod Res. 2017 Dec;31(23):2810-2813.|[2]Gao B, et al. Active constituents from Aloe arborescens as BACE inhibitors. Yao Xue Xue Bao. 2006 Oct;41(10):1000-3.|[3]Nakagomi K, et al. Inhibition by aloenin and barbaloin of histamine release from rat peritoneal mast cells[J]. Agricultural and biological chemistry, 1987, 51(6): 1723-1724.|[4]Deora N, et al. Lipase activity inhibited by aloenin A: Glycoside from Aloe vera (L.) Burm. f.-In vitro and molecular docking studies. J Mol Recognit. 2023 Feb;36(2):e3002.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  38412-46-3