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Aloin-A

CAT: 0804-HY-N0123-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0123-01Size:50 mg
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Description
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) [1][2][3][4].
CAS Number
1415-73-2
Product Name Alternative
Barbaloin-A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Wnt
Type
Natural Products
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Aloin.html
Concentration
10mM
Purity
99.31
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2O)[C@H]([C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C4=CC(CO)=CC(O)=C14
Molecular Formula
C21H22O9
Molecular Weight
418.39
Precautions
H302, H315, H319, H335
References & Citations
[2]Tabolacci C, et al. Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids. 2013 Jan;44 (1) :293-300.|[3]Cui Y, et al. Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice. Arch Pharm Res. 2014 Dec;37 (12) :1624-33.|[4]Pengjam Y, et al. Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling. Biomol Ther (Seoul) . 2016 Mar 1;24 (2) :123-3|[5]Jing Y, et al. Aloin Protects Against Blood-Brain Barrier Damage After Traumatic Brain Injury in Mice. Neurosci Bull. 2020 Jun;36 (6) :625-638.|[1]Pan Q, et al. Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 2013 Jul 12;13 (1) :69.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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292367-01Aloin
TRC-A575415-100MGAloin A

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