Cucurbitacin E

• Description:

  Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

• Product Name Alternative:

  α-Elaterin; α-Elaterine

• UNSPSC:

  12352211

• Hazard Statement:

  H302

• Target:

  Autophagy; CDK

• Type:

  Natural Products

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cucurbitacin-E.html

• Purity:

  99.92

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O[C@H] (C1) [C@@] ([C@@] (C) (O) C (/C=C/C (OC (C) =O) (C) C) =O) ([H]) [C@] (C2) (C) [C@]1 (C) [C@]3 ([H]) CC=C4C (C) (C) C (C (O) =C[C@@]4 ([H]) [C@]3 (C) C2=O) =O

• Molecular Formula:

  C32H44O8

• Molecular Weight:

  556.69

• Precautions:

  H302

• References & Citations:

  [1]Hsu YC, et al. Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E. Cell Death Dis. 2014 Apr 24;5:e1198.|[2]Murtaza M, et al. Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. PLoS One. 2017 Jun 9;12 (6) :e0178910.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CDK1

• CAS Number:

  18444-66-1