Cucurbitacin E

CAT: 0804-HY-N0417-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0417-01Size:1 mg
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Description
Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.
CAS Number
[18444-66-1]
Product Name Alternative
α-Elaterin; α-Elaterine
UNSPSC
12352211
Hazard Statement
H302
Target
Autophagy; CDK
Type
Natural Products
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cucurbitacin-E.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C(C(O)=C[C@@]4([H])[C@]3(C)C2=O)=O
Molecular Formula
C32H44O8
Molecular Weight
556.69
Precautions
H302
References & Citations
[1]Hsu YC, et al. Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E. Cell Death Dis. 2014 Apr 24;5:e1198.|[2]Murtaza M, et al. Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. PLoS One. 2017 Jun 9;12 (6) :e0178910.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CDK1

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