Cucurbitacin E

• Description :

  Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

• CAS Number :

  [18444-66-1]

• Product Name Alternative :

  α-Elaterin; α-Elaterine

• UNSPSC :

  12352211

• Hazard Statement :

  H302

• Target :

  Autophagy; CDK

• Type :

  Natural Products

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Cucurbitacin-E.html

• Purity :

  99.92

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C(C(O)=C[C@@]4([H])[C@]3(C)C2=O)=O

• Molecular Formula :

  C32H44O8

• Molecular Weight :

  556.69

• Precautions :

  H302

• References & Citations :

  [1]Hsu YC, et al. Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E. Cell Death Dis. 2014 Apr 24;5:e1198.|[2]Murtaza M, et al. Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. PLoS One. 2017 Jun 9;12 (6) :e0178910.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  CDK1