Products for Research Use Only
RegisterLogin

Cucurbitacin IIb

CAT: 0804-HY-N1987-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N1987-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1].
CAS Number
50298-90-3
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cucurbitacin-iib.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]([C@@](CC=C1[C@@]2([H])C[C@H](O)[C@@H](O)C1(C)C)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(CCC(C)(O)C)=O)[C@@]4(C3)C
Molecular Formula
C30H48O7
Molecular Weight
520.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang Y, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PLoS One. 2014 Feb 25;9 (2) :e89751.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N4175-01Cucurbitacin A
HY-N1405-01Cucurbitacin I
HY-N0417-01Cucurbitacin E
HY-N12461Cucurbitacin F
HY-N0416-01Cucurbitacin B
HY-N9968Cucurbitacin C
HY-N1986-01Cucurbitacin D
HY-N0725Cucurbitacin S
HY-N11080Cucurbitacin R
HY-N8137-01Cucurbitacin Q1

Alternative Products

CatalogName
RM-C212001-01Cucurbitacin A
N2201-20Cucurbitacin Ⅱa
N2791-20Cucurbitacin E
ZDA53082-01Cucurbitacin Q1
TN5990Cucurbitacin V
TQ0196-01Cucurbitacin I
371322Cucurbitacin A discontinued
445161-01Cucurbitacin D
AB0583Cucurbitacin C
AB0291-01Cucurbitacin IIb

Popular Products