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Dalargin

CAT: 0804-HY-P4053-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P4053-02Size:10 mg
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Description
Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin -induced cell death. Dalargin shows nephroprotective effects on Gentamicin (HY-A0276A) -induced kidney injury. Dalargin shows antiulcer activity[1][2][3].
CAS Number
81733-79-1
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dalargin.html
Purity
99.52
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)CC2=CC=CC=C2)=O)=O
Molecular Formula
C35H51N9O8
Molecular Weight
725.83
References & Citations
[1]Titov MI, et al. Dalargin--a peptidnyĭ preparat s tsitoprotektivnym deĭstviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8 (2) :72-6.|[2]Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220 (3) :303-8.|[3]Polonskiĭ VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo deĭstviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'noĭ modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103 (4) :433-4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR

Chemical Information

Dalargin

RN refers to (L-Arg-L-Tyr-D-Ala-L-Phe-L-Leu)-isomer

CAS Number81733-79-1
PubChem CID6917894
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular FormulaC35H51N9O8
Molecular Weight725.8
XLogP-2.5
Topological Polar Surface Area293
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count10
Rotatable Bond Count21
Heavy Atom Count52
Formal Charge0
Complexity1210
SMILES
C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChI
InChI=1S/C35H51N9O8/c1-20(2)16-27(32(49)43-26(34(51)52)10-7-15-39-35(37)38)44-33(50)28(18-22-8-5-4-6-9-22)42-29(46)19-40-30(47)21(3)41-31(48)25(36)17-23-11-13-24(45)14-12-23/h4-6,8-9,11-14,20-21,25-28,45H,7,10,15-19,36H2,1-3H3,(H,40,47)(H,41,48)(H,42,46)(H,43,49)(H,44,50)(H,51,52)(H4,37,38,39)/t21-,25+,26+,27+,28+/m1/s1
InChIKey
GDPHPXYFLPDZGH-XBTMSFKCSA-N
Chemical Structure
2D Structure
2D structure of Dalargin
CAS: 81733-79-1
CID: 6917894
Formula: C35H51N9O8
MW: 725.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight725.8
XLogP3-2.5
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count10
Rotatable Bond Count21
Exact Mass725.38605962
Monoisotopic Mass725.38605962
Topological Polar Surface Area293 Ų
Heavy Atom Count52
Formal Charge0
Complexity1210
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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