Didox

• Description :

  Didox (NSC-324360) is a synthetic ribonucleotide reductase (RR) inhibitor.

• CAS Number :

  [69839-83-4]

• Product Name Alternative :

  NSC-324360

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Didox.html

• Concentration :

  10mM

• Purity :

  98.03

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NO)C1=CC=C(O)C(O)=C1

• Molecular Formula :

  C7H7NO4

• Molecular Weight :

  169.13

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Matsebatlela TM, et al. 3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages. Chem Biol Interact. 2015 May 25;233:95-105.|[2]Cook GJ, et al. The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML. PLoS One. 2014 Nov 17;9 (11) :e112619.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2