FGFR1/VEGFR2-IN-3

FGFR1/VEGFR2-IN-3

• UNSPSC Description: FGFR1/VEGFR2-IN-3 (Compound 8m) is a dual inhibitor of FGFR1/VEGFR2. FGFR1/VEGFR2-IN-3 exhibits anti-proliferative and anti-migratory activities against cancer cells, and is capable of inducing cell apoptosis[1].
• Target Antigen: Apoptosis; FGFR; VEGFR
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fgfr1-vegfr2-in-3.html
• Smiles: O=C(NN1C(C(C=C(C=CC=C2)C2=C3)=C3C1=O)=O)C4=CC=C5NC(C6=CC=C(OC)C=C6)=NC5=C4
• Molecular Weight: 462.46
• References & Citations: [1]Abdel-Mohsen H T, et al. Benzimidazole–dioxoisoindoline conjugates as dual VEGFR-2 and FGFR-1 inhibitors: design, synthesis, biological investigation, molecular docking studies and ADME predictions[J]. RSC advances, 2024, 14(39): 28889-28903.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported