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Gly-Pro-Glu

CAT: 0804-HY-117483-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117483-01Size:5 mg
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Description
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].
CAS Number
32302-76-4
Product Name Alternative
ABBV-075
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gly-pro-glu.html
Purity
99.64
Solubility
DMSO : 66.67 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)
Smiles
O=C(CC[C@H](NC([C@H]1N(CCC1)C(CN)=O)=O)C(O)=O)O
Molecular Formula
C12H19N3O6
Molecular Weight
301.30
References & Citations
[1]Sara VR, et al. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989 Dec 15;165 (2) :766-71.|[2]Aguado-Llera D, et al. Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex. Neuroreport. 2004 Aug 26;15 (12) :1979-82.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 4

Chemical Information

Glycyl-prolyl-glutamic acid

Gly-Pro-Glu is a tripeptide.

CAS Number32302-76-4
PubChem CID3080768
IUPAC Name(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]pentanedioic acid
Molecular FormulaC12H19N3O6
Molecular Weight301.30
XLogP-5.1
Topological Polar Surface Area150
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count21
Formal Charge0
Complexity439
SMILES
C1C[C@H](N(C1)C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI
InChI=1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
InChIKey
JJGBXTYGTKWGAT-YUMQZZPRSA-N
Chemical Structure
2D Structure
2D structure of Glycyl-prolyl-glutamic acid
CAS: 32302-76-4
CID: 3080768
Formula: C12H19N3O6
MW: 301.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight301.30
XLogP3-5.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass301.12738533
Monoisotopic Mass301.12738533
Topological Polar Surface Area150 Ų
Heavy Atom Count21
Formal Charge0
Complexity439
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-P3280-01γ-Glu-Gly
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HY-P3941Ala-Arg-Arg-Pro-Glu-Gly-Arg-Thr-Trp-Ala-Gln-Pro-Gly-Tyr
HY-P4905Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap (Dnp) -NH2
HY-P2718Z-Gly-Pro-Gly-Gly-Pro-Ala-OH
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Alternative Products

CatalogName
TRC-G650313-100MGGly-Pro-Glu
035-04Gly-Pro-Glu (GPE) (Human)
4099720.1000Cyclo (-Gly-Arg-Gly-Glu-Ser-Pro)
4099720.1Cyclo(-Gly-Arg-Gly-Glu-Ser-Pro)
025-31GRGESP (Gly-Arg-Gly-Glu-Ser-Pro)
H-3136.0005H-Gly-Arg-Gly-Glu-Ser-Pro-OH
FG109087-01H-Gly-Arg-Gly-Glu-Thr-Pro-OH
SP-52292-1Pancreastatin, Porcine [Gly-Trp-Pro-Gln-Ala-Pro-Ala-Met-Asp-Gly-Ala-Gly-Lys-ThrGly-Ala-Glu-Glu-Ala-Gln-Pro-Pro-Glu-Gly-Lys-Gly-Ala-Arg-Glu-His-Ser-Arg-Gln-Glu-Glu-Glu-Glu-Glu-THr-Ala-Gl-Ala-Pro-Gln-Gly-Leu-Phe-Arg-Glu-NH2; MW: 513.4]
MBS658401-01Fibronectin Fragment (Tyr-Glu-Lys-Pro-Gly-Ser-Pro-Pro-Arg-Glu-Val-Val-Pro-Arg-Pro-Arg-Gly-Val)
H-8224.0001H-Gly-Gly-Arg-Ser-Pro-Ala-Met-Pro-Glu-OH

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