AMC-01

• Description :

  AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB) . AMC-01 inhibits apoptosis[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Eukaryotic Initiation Factor (eIF)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/amc-01.html

• Purity :

  99.38

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)C(O)=O.COC1=CC=C(Br)C=C1CN2CCN(C(C3=CC=C(C4=CC=CC=C4)C=C3)=O)CC2

• Molecular Formula :

  C27H27BrN2O6

• Molecular Weight :

  555.42

• References & Citations :

  [1]Hong MN, et al. The small molecule '1- (4-biphenylylcarbonyl) -4- (5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 May;21 (3) :485-97.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1047978-71-1]