PARP-1-IN-2

PARP-1-IN-2

• CAS Number: 684234-55-7
• UNSPSC Description: PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].
• Target Antigen: Apoptosis; Caspase; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/parp-1-in-2.html
• Solubility: DMSO : 83.33 mg/mL (ultrasonic)
• Smiles: O=C(NC1=CC=CC(Cl)=C1)CN(N=C(C2=CC=C(Cl)C=C2)C3=C4C=CC=C3)C4=O
• Molecular Weight: 424.28
• References & Citations: [1]Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported