Human Recombinant NR5A1 (C247S, C412S mutant)

• Description:

  Human Recombinant NR5A1 (C247S, C412S mutant)_x000D_ Catalog number: B2017633_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 31.01 kDa_x000D_ Supplied as: SOLUTION_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Ad4BP, Adrenal 4-binding Protein, Fushi Tarazu Factor Homolog 1, Nuclear Receptor Subfamily 5 Group A Member 1, SF-1, Steroidogenic Factor 1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Huh K, Nah WH, Xu Y, Park MJ, Gye MC. Effects of Recombinant Human Growth Hormone on the Onset of Puberty, Leydig Cell Differentiation, Spermatogenesis and Hypothalamic KISS1 Expression in Immature Male Rats World J Mens Health. 2021 Apr;39(2):381-388._x000D_ 2: Kim KP, Choi J, Yoon J, Bruder JM, Shin B, Kim J, Arauzo-Bravo MJ, Han D, Wu G, Han DW, Kim J, Cramer P, Schöler HR. Permissive epigenomes endow reprogramming competence to transcriptional regulators Nat Chem Biol. 2021 Jan;17(1):47-56._x000D_ 3: Voican A, Bachelot A, Bouligand J, Francou B, Dulon J, Lombès M, Touraine P, Guiochon-Mantel A. NR5A1 (SF-1) mutations are not a major cause of primary ovarian insufficiency J Clin Endocrinol Metab. 2013 May;98(5):E1017-21._x000D_ 4: Sugawara T, Kiriakidou M, McAllister JM, Holt JA, Arakane F, Strauss JF 3rd. Regulation of expression of the steroidogenic acute regulatory protein (StAR) gene: a central role for steroidogenic factor 1 Steroids. 1997 Jan;62(1):5-9._x000D_ 5: Bassett MH, Zhang Y, Clyne C, White PC, Rainey WE. Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1 J Mol Endocrinol. 2002 Apr;28(2):125-35._x000D_ 6: Christenson LK, Johnson PF, McAllister JM, Strauss JF 3rd. CCAAT/enhancer-binding proteins regulate expression of the human steroidogenic acute regulatory protein (StAR) gene J Biol Chem. 1999 Sep 10;274(37):26591-8._x000D_ 7: Laverrière JN, Granger A, Pincas H, Ngô-Muller V, Bleux C, Tixier-Vidal A, Magre S, Guigon C, Daegelen D, Counis R. [An ambiguous role of steroidogenic factor 1 in the rat GnRH receptor gene expression. Lessons from transgenic mice] J Soc Biol. 2004;198(1):73-9._x000D_ 8: Tantawy S, Mazen I, Soliman H, Anwar G, Atef A, El-Gammal M, El-Kotoury A, Mekkawy M, Torky A, Rudolf A, Schrumpf P, Grüters A, Krude H, Dumargne MC, Astudillo R, Bashamboo A, Biebermann H, Köhler B. Analysis of the gene coding for steroidogenic factor 1 (SF1, NR5A1) in a cohort of 50 Egyptian patients with 46,XY disorders of sex development Eur J Endocrinol. 2014 Apr 10;170(5):759-67._x000D_ 9: Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M. Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination Genesis. 2015 Jun;53(6):387-93._x000D_ 10: Shibata H, Kobayashi S, Kurihara I, Suda N, Yokota K, Murai A, Ikeda Y, Saito I, Rainey WE, Saruta T. COUP-TF and transcriptional co-regulators in adrenal steroidogenesis Endocr Res. 2004 Nov;30(4):795-801. _x000D_ _x000D_ Products Related to Human Recombinant NR5A1 (C247S, C412S mutant) can be found at Proteins

• Short Description:

  Catalog Number: B2017633 (50 µg)_x000D_ NR5A1, also known as Steroidogenic Factor 1 (SF-1), is a transcription factor critical for adrenal gland and gonad development. C247S and C412S mutations alter NR5A1's structure and function, impacting gene expression and hormone production. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3