Communic acid

• UNSPSC Description:

  Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC50 of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging[1][2][3].

• Target Antigen:

  Akt; Bacterial; MMP

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease;PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/communic-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]1([C@H]2C/C=C(C)/C=C)[C@](CCC2=C)([H])[C@](C)(CCC1)C(O)=O

• Molecular Weight:

  302.45

• References & Citations:

  [1]Samoylenko V, et al. Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. Phytother Res. 2008;22(12):1570-1576.|[2]Huh WB, et al. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K. PLoS One. 2015;10(6):e0128365. Published 2015 Jun 11.|[3]Carpenter CD, et al. Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis. J Ethnopharmacol. 2012;143(2):695-700.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2761-77-5