ITGAE (heavy chain, Cleaved-Ala179) rabbit pAb

• Background:

  Integrin subunit alpha E (ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

• Description:

  Integrin subunit alpha E (ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],

• UniProt:

  P38570

• Swiss Prot:

  P38570

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human ITGAE (heavy chain, Cleaved-Ala179)

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300

• Molecular Weight:

  110 128kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  110 128kD

• Fragment:

  IgG

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Other Product Names:

  Integrin alpha-E (HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]

• Gene ID (Human):

  3682