BiKEAP1

CAT: 0804-HY-162152-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-162152-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

BiKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models[1].

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bikeap1.html

Purity

99.44

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(S(=O)(NC2=C3C=CC=CC3=C(N(CC(O)=O)S(=O)(C4=CC=C(OC)C=C4)=O)C=C2)=O)C=C1)CCC(NCCCNC(CCC(NC5=CC=C(S(=O)(NC6=C7C=CC=CC7=C(N(CC(O)=O)S(=O)(C8=CC=C(OC)C=C8)=O)C=C6)=O)C=C5)=O)=O)=O

Molecular Formula

C61H60N8O18S4

Molecular Weight

1321.43

References & Citations

[1]Lu M, et al. Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response. Cell Chem Biol. 2023 Dec 21:S2451-9456 (23) 00435-X.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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